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Psychedelic drug Wikipedia Open label clinical trials are designed when both the researcher and the participant are aware of the treatment to be received (control/placebo or test drug in a two-arm clinical design). This type of trial design is converse to double blind studies in which neither the researcher nor the participant are aware of the treatment to be received. It is notable that regardless of the trial design, the type of treatment to be received can still be randomized. Users have also reported encountering and communicating with entitites within this hallucinatory state. DMT is the archetypal substituted tryptamine, being the structural scaffold of psilocybin and - to a lesser extent - the lysergamides. The term psychedelic was coined by the psychiatrist Humphrey Osmond during written correspondence with author Aldous Huxley and presented to the New York Academy of Sciences by Osmond in 1957. It is irregularly derived from the Greek words ψυχή psychḗ 'soul, mind' ...